Project Description
Implementation of in-line analytical technologies and real-time release testing into continuous manufacturing processes of solid pharmaceutical manufacturing, starting from the crystallization step through the final tablet product.
Application and development mechanistic, statistical and chemometric models for the evaluation of Process Analytical Technology (PAT) data and optimization of the pharmaceutical processes.
Awards and Honors
Scholarship of the Rosztoczy Foundation (2019)
Publications and Presentations
Journal Publications
B. NAGYA. FARKAS, E. BORBÁS, P. VASS, ZS. K. NAGY, GY. MAROSI Raman spectroscopy for Process Analytical Technologies of Pharmaceutical Secondary Manufacturing,AAPS PharmSciTech (2019) 20: 1.
B. NAGY, A. FARKAS, K. MAGYAR, B. DÉMUTH, ZS. K. NAGY, GY. MAROSI Spectroscopic characterization of tablet properties in a continuous powder blending and tableting process,European Journal of Pharmaceutical Sciences, 123, 2018, 10-19
B. NAGYA. FARKAS, M. GYÜRKÉS, SZ. KOMAROMY-HILLER, B. DÉMUTH, B. SZABÓ, D. NUSSER, E. BORBÁS, GY. MAROSI, ZS. K. NAGY, In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process, International Journal of Pharmaceutics 530 (1-2), 2017, 21-29
B. NAGY, A. FARKAS, A. BALOGH, H. PATAKI, B. VAJNA, ZS. K. NAGY, GY. MAROSI, Quantification and handling of nonlinearity in Raman micro-spectrometry of pharmaceuticals, Journal of Pharmaceutical and Biomedical Analysis, 128, 2016, 236-246
A. FARKAS,B. NAGY , B. DÉMUTH, A. BALOGH, H. PATAKI, ZS. K. NAGY, GY. MAROSI, Variable clustering and spectral angle mapper-orthogonal projection method for Raman mapping of compound detection in tablets, Journal of Chemometrics , 31(1), 2017, 1-11
Conference Presentation
“B. NAGYA. FARKAS, P. DULICHÁR, K. MAGYAR, ZS. K. NAGY, GY. MAROSI Non-destructive spectroscopic analysis and artificial intelligence for dissolution prediction of pharmaceutical tablets 12th Central European Symposium on Pharmaceutical Technology and Regulatory Affairs Szeged, Hungary, 2018
“B. NAGY, A. FARKAS, L. MADARÁSZ, B. DÉMUTH, ZS. K. NAGY, GY. MAROSI Complementary PAT tools for twin-screw wet granulation- toward a Process Analytically Controlled Technology The Ninth pan-European Conference on PAT and QbD Sciences,, Manchester, UK, 2018
“B. NAGYA. FARKAS, M. GYÜRKÉS, GY. MAROSI, ZS.K. NAGY, In-line Raman spectroscopic monitoring and feedback control of a continuous pharmaceutical powder blending and tableting process 7th BBBB Conference on International Conference on Pharmaceutical Sciences Balatonfüred, Hungary, 2017
Education
|
